Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Do not forget why you're attending these conferences, who you're doing this for -- we are your own children. You are deciding what kind of world we will grow up in. Parents should be able to comfort their children by saying "everyting's going to be alright" , "we're doing the best we can" and "it's not the end of the world". 不要忘记你们为何而来到这里开会，你们为谁做事情？我们是你们的下一代，你们正在决定我们将要在一个什么样的环境中成长，父母需要能够宽慰孩子们，告诉他们“一切都没问题，那不是世界末日，我们正在尽其所能的改变”。
位于加州的斯坦福大学商学院(Stanford Graduate School of Business)排名第二，2016年排在第五位，该学院曾在2014年获得亚军。宾夕法尼亚大学沃顿商学院(Wharton School of the University of Pennsylvania)排名第三。
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The seven large brick tombs were likelyconstructed for people of wealth, the researchers said.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
20. Best Advice for Movie Lovers In August, the scholar Wheeler Winston Dixon sounded an alarm: “If you go on Amazon and you see some great black-and-white film, and it’s going for $3, or any kind of foreign or obscure film, buy it, because it’s going out of print, and they’re not going to put them back into print.” Tens of thousands of films that were on VHS never made the jump to DVD or to Blu-ray, Mr. Dixon warns. And the brave new world of downloads (a.k.a. electronic sell-through) — well, tune in next year.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
In a close second was Changsha, capital of Hunan province, with growth of 4.5.
Trends and targets in antiviral phototherapy
“能够有这些天赋异禀的艺术家为电影的音乐进行神助攻，我们非常能高兴。”这场秀的制作人Michael De Luca 和Jennifer Todd周五发表申明时如是说。“能邀请到他们登上第90届奥斯卡也是一种荣幸。”
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Finally, in the EMBA ranking, excluding joint programmes delivered with non-European schools, IMD of Switzerland, with an average salary of $261,397, is well ahead of Business School in second and IE Business School in third place.
Novel biosensing methodologies for ultrasensitive detection of viruses
The soaring prices of 2008, when oil reached more than $140 a barrel, will repeat, though not likely in 2014, Mr. Hummel said. The price 'is going to go higher.'
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Venezuela's government closed all crossings a year ago to crack down on smuggling along the 1378-mile (2219 kilometer) border. It complained that speculators were causing shortages by buying up subsidized food and gasoline in Venezuela and taking them to Colombia where they could be sold for far higher prices.
有些热门剧已经走得太远，应该降降温了，却仍在大张旗鼓，比如《唐顿庄园》(Downton Abbey)、《丑闻》(Scandal)和《复仇》(Revenge)。ABC频道的新剧《逍遥法外》(How to Get Away With Murder)是一部有趣的替代品，它是一部耸人听闻的夜间肥皂剧，讲述不法辩护律师的故事，简直可以称为“法律与无序”。
ACE2 as a potential therapeutic target for pandemic COVID-19
Despite our global economy, only 20 percent of Americans speak another language. Sixty Vocab is aiming to change that with it’s online foreign language game. Based on the premise that 2000 words equals 60 percent of a foreign language, Sixty Vocab is aiming to make learning essential vocabulary fun. The games teach the words most commonly used in conversation and applies time-based discipline — the faster you guess the word, the more rapidly you move on to the next one. Bridging the gap between your high school classes and a pricey foreign language program, Sixty Vocab is offering a unique option for those who want to learn a foreign language during their morning coffee or commute.
After weeks of rumors, Phil Jackson failed to move Carmelo Anthony and Derrick Rose, two players who absolutely should have been traded for the long-term benefit of the franchise.
Diagnostic technologies for COVID-19: a review
It was last above 50 - the threshold separating contraction from expansion - in February.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Andrew Hill is management editor
The National Basketball Association (NBA) Global Games is to feature two pre-season games in China between the Golden State Warriors and the Minnesota Timberwolves, the NBA announced.
企业也在其他方面受益。英国国家电网公司的业务分析经理克雷格?罗拉森(Craig Rollason)表示，他通过指导一位Teach Firste人提高了自己的指导技巧。
HEC Paris is second despite outperforming LBS in all rankings but the MBA. It missed out on a full house because of its participation in the executive MBA ranking as one-third of Trium, the programme delivered jointly with London School of Economics and New York’s Stern School of Business. (Schools participating in the EMBA ranking with joint programmes receive a proportionate score.)
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
?The Aston Martin doesn't hurt. Not at all. Neither does dropping tons of cash at exotic casinos -- throwing money around makes men more attractive to women who are interested in flings. And, like Bond, men who gamble with women around are better at it.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
A total of 13.14 million new urban jobs were added.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
'If global demand picks up in the developed world, and you combine that with the growth in the emerging economies, I think the market is going to get tight,' he said, which means those mighty peaks could return to the oil-price graph.
Antiviral drug discovery: broad-spectrum drugs from nature
Global emissions of greenhouse gases jumped 2.3 percent in 2013 to record levels, scientists reported Sunday, in the latest indication that the world remains far off track in its efforts to control global warming.
2.Yeah, I’ll start working on that ASAP! – Because telling you I have 10 things to do first would just irritate you。
5. 地缘政治事件。不久之前，石油供应稍有差池，油价就会飙升。比如说2014年初，利比亚内乱造成该国石油出口中断，油价应声上涨。在伊拉克， 极端组织ISIS领了部分地区，石油供应中断的顾虑也造成油价急剧攀升。然而，自此之后，地缘政治事件对油价的影响大为减弱。2014年最后几周，利比亚再现战事。但市场仅在油价短暂上扬后便把这一问题抛诸脑后。不过，历史一再证明，地缘政治危机是对油价影响最大的短期因素之一。（财富中文网）
Influenza neuraminidase: A druggable target for natural products
Written instructions apparently issued by China’s tourism administration, shown to the FT by one Beijing travel agent, order agencies to cancel group tours to South Korea booked for after March 15 and add that companies not in compliance could be fined or have their licences revoked. The tourism administration was not immediately available for comment.
Her device uses carbon nanotubes to detect the presence of lead. Thousands of US water systems are reportedly contaminated by lead.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
7. Get Comfortable
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
“Tangerine” (Sean Baker)
"This is something we believe is really important for the future of our country,"Facebook (FB, Fortune 500) CEO Mark Zuckerberg said in August.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
在数十项小型、以科技为核心的收购中，对Beats Electronics的30亿美元收购成为苹果迄今最大的一笔收购。Beats Electronics是一家有著名音乐人背景的耳机制造商和音乐流媒体服务商。这笔收购仍然让许多苹果分析师感到困惑，但与Beats创始人吉米?艾欧文(Jimmy Iovine)和安德烈?罗米尔?扬(Dr. Dre)合作，让苹果忽略iTunes下载商店数年后，迅速在音乐界重建信誉。如果说库克对错过类似Spotify的音乐订阅服务的快速增长感到愧疚，那么他已迅速弥补了这一点——尽管付出了很高代价。
Paramore, 'After Laughter'
Wang Jie, the general manager of a Beijing-based investment company, said the higher pay for executives in the financial and real estate industries shows the imbalance of development in China.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
While 17 per cent of graduates rated starting a company as joint most important reason, only 2 per cent of them saw it as their main sole ambition. However, entrepreneurship is clearly growing on them, as more than a quarter of graduates (26 per cent) reported starting their own company during their EMBA or since graduating.
File this under "great, yet stupid gift ideas." The BOx bottle opener claims to be the "world's first smart bottle opener" but it's not groundbreaking. This bottle opener sends a message to your friends via Messenger every time you open a bottle — crazy, right?
Inhibition of SARS coronavirus helicase by bismuth complexes
There’s nothing worse than a boss who says one thing and does another, and nothing better than one who keeps his word. Just as managers must trust their team, employees must trust their boss to have their best interests at heart。
Gitanjali said she wanted to further refine the device so it could eventually go on the market.
Bad news for newspaper reporters: Your job has been named the worst in the U.S. for 2015, according to rankings released by job search site CareerCast.com. Two other media positions are also high on the list, along with professions that are physically taxing.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The Norwegian Nobel Committee made the announcement Friday in Oslo, saying the three women will split the coveted award for "their nonviolent struggle for the safety of women and for women's rights."
There are few chief executive decisions that drew more attention this year than Yahoo(YHOO, Fortune 500) CEO Marissa Mayer's work-from-home ban. The policy was initially seen as highly controversial and had a lot of people upset because of its perceived lack of flexibility.
"We hope the mother will come to us and verify the facts. If it's true that the user is a 13-year-old who spent the money without consent, we can negotiate a refund," the Tencent employee said.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Best chances: A best film nomination looks certain. Darkest Hour's Gary Oldman is the favorite for best actor, but if anyone can beat him it's probably Chalamet.
"It's a goal that's right here and now and it's something that we want to experience," Curry said. "It'd be a huge accomplishment because doing something that hasn't been done in the history of the league is special. You never know if this opportunity will come back again. There are so many variables that go into winning this many in a row, especially the start of the season."
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
《前第一夫人要求伊斯兰教变得宽容并支持女权》(A Former First Lady Presses On for a Tolerant, Feminist Islam)
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
In 2011 the owner of the tomb was identified as Liu Fei (169BC-127BC) the first king of Jiangdu an autonomous kingdom within the Han Dynasty according to China News.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Against: To some extent it's divided American audiences, perhaps damaging its hopes of winning best film.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
'For what is really exceptional, not seen on the market, there are really clients looking for such investments,'
However, we are sceptical that the strength of imports can be sustained given that the delayed impact of policy tightening and a cooling property market are set to weigh on Chinese demand for commodities in coming quarters.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
This way you can tell everyone to shut up and get out so you can go to your "mind palace".
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
You've usually stated in pastinterviews that you have connections to your characters. In Aldnoah Zero, whichis currently airing, what do you think is your connection to Inaho?
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Since Sunday, viewers everywhere have been in mourning, at least judging by the Twitterati.
Wishing you a sparkling New Year and bright happy New Year! May the season bring much pleasure to you.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Internet tycoons had heated discussions on the promise of artificial intelligence (AI) following the historic victory earlier this month for Google Inc's AI-powered AlphaGo over South Korean Go master Lee Se-dol.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Developer: Remedy Entertainment, Microsoft Studios
Mila Kunis just keeps on raking in those sexy titles.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
（G.I. Joe: Retaliation）以及两部小规模电影，加起来在全球的票房收入总计13亿美元。
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
“I thought it would be impossible to replace Steve, and to some extent that’s true,” says Professor Michael Cusumano of MIT’s Sloan School of Management. “But internally the spirit is still alive and the company is organising around a less confrontational culture. We have to give Tim credit for that.”
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
FOYLE’S WAR (acorn.tv, Feb. 2) After nabbing the final three episodes of “Agatha Christie’s Poirot” last year, the streaming service Acorn TV scores another coup in the field of traditional British mysteries with the American premiere of this superior show’s ninth season. Starring Michael Kitchen as Christopher Foyle, a detective as honorable as he is shrewd, the series has morphed over the years from a provincial home-front cop show to a le Carré-like Cold War thriller. New episodes involve the Nuremberg trials and Britain’s role in Palestine.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Amid rising pollution and a strengthening yuan, the capital city saw its tourist numbers drop to 4.20 million visits from January to November from 5.01 million visits in 2012, according to China Daily, citing a report from China Tourism Academy and Beijing Commission of Tourism Development. An earlier report based on a survey of domestic travel agents showed that visitors to the capital declined by roughly 50% in the first three-quarters of the year compared with a year earlier.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
You’re a busy person. At times, it all can feel overwhelming. Asana is a cloud-based project management software that helps you keep it together. (Trust me, I’ve tried them all.) Flexibility is built into Asana’s architecture. Each “task”, or “subtask”, can be associated with a larger “project” and “department.” In addition, you can even assign recurring tasks to yourself or team, which makes life so much easier. Stop trying to remember all the things you’re supposed to do and let Asana structure your life.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
The Internet users posted screenshots from social networking apps showing questions and answers that were going to be on the exam.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
When I find myself wanting to shout “No!” to an opportunity, that’s a sure sign to me that the answer should probably be “Yes.” So, I take a deep breath and analyze the situation as objectively as possible.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Movie buffs will soon be able to celebrate with a visual feast at the Beijing International Film Festival, where nearly 500 high quality films will be shown.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
The highest scoring tournament: 1994 in theUnited Stateswhen 24 teams averaged 2.97 over 52 matches.
Brazil lost that 1950 final, 2-1, to Uruguay, a historic humiliation that still stings Brazilian fans today. Belmonte, 85, hopes he'll get to see his country regain its honor. "I hope Brazil will be able to win this time," he said. "This is our revenge. I want to go see our revenge."
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Stanford’s alumni have the highest salary on average at $195,000 but overall the top 15 MBA programmes are closely matched in terms of income, career progress and satisfaction. All but one have average alumni salaries greater than $150,000, with a pay increase of about 100 per cent compared with their pre-MBA income.
Length-scale dependence of protein hydration-shell density
The refugees have streamed into Greece, Bulgaria, Italy, Spain, Malta and Cyprus during 2015, with a huge majority -- over 800,000 -- arriving by sea in Greece. About 3,600 died or disappeared trying to make the perilous Mediterranean Sea crossing between North Africa and Italy.
In being named CEO, Mary Barra broke through several historical barriers in moving from GM's third-most powerful executive position to its first. Her job was made both easier by the appointment of a non-executive chairman to handle the board of directors, and more difficult by the decision to give her old job to one of her rivals. As the first product engineer to head the company in two decades, she will be deluged with suggestions about everything from air conditioning vents in new pickups to the future of brands like Buick and Chevrolet.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
4. gam / n . <俚> (尤指美丽女子的) 腿。
WTF.1: Next Level of Working Moms
In early December, authorities announced that market circuit breakers would be introduced become effective from January 1 in an effort to limit the volatility seen during the savage, summer sell-off from June. The circuit breakers would see trading in shares, options and futures halted for 15 minutes if they fell by more than 5 per cent. On their first day of use, that first threshold was breached just after the return from the lunchbreak, prompting a 15-minute halt.
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Some of the leaked photos and videos can still be found on Chinese social media as of press time.